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歐盟評估豬胰腺中胰蛋白酶和胰凝乳蛋白酶的安全性

   2021-06-17 食品伙伴網澤夕1022
核心提示:   2021年6月16日,歐盟食品安全局就食品酶胰蛋白酶和胰凝乳蛋白酶(trypsin and chymotrypsin)的安全性評價發布意見。  據
     2021年6月16日,歐盟食品安全局就食品酶胰蛋白酶和胰凝乳蛋白酶(trypsin and chymotrypsin)的安全性評價發布意見。 
  據了解,這種食品酶來自豬胰腺,旨在用于蛋白質加工以及水解乳蛋白中。
 
  經過評估,專家小組得出結論,該食用酶在用于生產基于乳蛋白水解物的嬰兒配方奶粉時不會引起安全問題。部分原文報道如下:
 
  The food enzyme is a serine protease complex containing trypsin (EC 3.4.21.4) and chymotrypsin (EC 3.4.21.1) obtained from porcine pancreas by Paninkret Chem.-Pharm. Werk GmbH. The food enzyme is currently only used in protein processing to hydrolyse milk proteins. Milk protein hydrolysates and peptides are mainly used in formulae intended to have reduced allergenicity. based on the recommended use level and the high consumption of formulae in very young babies, dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be 180 mg TOS/kg body weight (bw) per day for infants and toddlers. Toxicological evaluation was based on the available clinical studies with pancreatic enzymes. Hypersensitivity to the product was identified as the major side effect. However, the intact enzymes are inactivated during preparation of food products; therefore, the Panel considered that the likelihood of adverse effects of the intact enzyme to occur is low. The Panel considered that a risk of allergic sensitisation to these protein hydrolysates after consumption cannot be excluded, but the likelihood of occurrence was considered to be low. based on the origin of the food enzyme from edible parts of animals, the data provided and the evaluation of clinical studies with pancreatic enzymes and the estimated dietary exposure, the Panel concluded that the food enzyme does not give rise to safety concerns when used in the production of infant formulae based on milk protein hydrolysates.
 
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日期:2021-06-17
 
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