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歐盟評估一種食品酶葡聚糖酶的安全性

   2020-12-10 食品伙伴網澤夕360
核心提示:   2020年12月9日,歐盟食品安全局就一種食品酶葡聚糖酶(dextranase)的安全性評價發布意見。  據了解,這種食品酶是由Coll
     2020年12月9日,歐盟食品安全局就一種食品酶葡聚糖酶(dextranase)的安全性評價發布意見。 
  據了解,這種食品酶是由Collariella gracilis 菌株ATCC‐16153生產的,旨在用于糖的生產和加工中。
 
  經過評估,專家小組認為,在預期的使用條件下,不能排除飲食暴露引起過敏和誘發反應的風險,但這種情況發生的可能性很低。根據提供的數據,小組得出結論,該食品酶在預期的使用條件下不會引起安全隱患。部分原文報道如下:
 
  The food enzyme dextranase (6‐α‐d‐glucan 6‐glucanohydrolase, EC 3.2.1.11) is produced with the non‐genetically modified Collariella gracilis strain ATCC‐16153 by Mitsubishi‐Kagaku Foods Corporation. The food enzyme is free from viable cells of the production organism. The food enzyme is intended to be used in sugar production and processing. As residual amounts of total organic solids (TOS) are removed during the production of refined sugars, dietary exposure was calculated only for unrefined sugar products. based on the maximum use levels, dietary exposure to the food enzyme TOS was estimated to be up to 15 μg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level (NOAEL) of 110 mg TOS/kg bw per day, the highest dose tested, which, when compared with the estimated dietary exposure, results in a sufficiently high margin of exposure (MoE) of at least 7,300. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
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日期:2020-12-10
 
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